SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage

Myofibroblast differentiation is a key process in the pathogenesis of fibrotic diseases. Transforming growth factor-β(1) (TGF-β(1)) is a powerful inducer of myofibroblast differentiation and is implicated in pathogenesis of tissue fibrosis. This study was undertaken to determine the role of mitochon...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Lung Cell Mol Physiol
Hoofdauteurs: Bindu, Samik, Pillai, Vinodkumar B., Kanwal, Abhinav, Samant, Sadhana, Mutlu, Gökhan M., Verdin, Eric, Dulin, Nickolai, Gupta, Mahesh P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283928/
https://ncbi.nlm.nih.gov/pubmed/27815257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00188.2016
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