The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

Sirtuins (Sirts) are implicated in regulating a myriad of biologic functions ranging from cell growth and metabolism to longevity. Here, we show that nuclear Sirt, Sirt6, and mitochondrial Sirt, Sirt3, regulate each other’s activity and protect the heart from developing diabetic cardiomyopathy. We f...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Kanwal, Abhinav, Pillai, Vinodkumar B., Samant, Sadhana, Gupta, Madhu, Gupta, Mahesh P.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766651/
https://ncbi.nlm.nih.gov/pubmed/31318577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900767R
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