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SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage
Myofibroblast differentiation is a key process in the pathogenesis of fibrotic diseases. Transforming growth factor-β(1) (TGF-β(1)) is a powerful inducer of myofibroblast differentiation and is implicated in pathogenesis of tissue fibrosis. This study was undertaken to determine the role of mitochon...
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| Veröffentlicht in: | Am J Physiol Lung Cell Mol Physiol |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5283928/ https://ncbi.nlm.nih.gov/pubmed/27815257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00188.2016 |
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