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Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice

Doxorubicin (Doxo) is a chemotherapeutic drug widely used to treat variety of cancers. One of the most serious side effects of Doxo is its dose-dependent and delayed toxicity to the heart. Doxo is known to induce cardiac mitochondrial damage. Recently, the mitochondrial sirtuin SIRT3 has been shown...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Am J Physiol Heart Circ Physiol
मुख्य लेखकों: Pillai, Vinodkumar B., Bindu, Samik, Sharp, Will, Fang, Yong Hu, Kim, Gene, Gupta, Madhu, Samant, Sadhana, Gupta, Mahesh P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Physiological Society 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867337/
https://ncbi.nlm.nih.gov/pubmed/26873966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00832.2015
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