Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

Since the discovery of NAD-dependent deacetylases, sirtuins, it has been recognized that maintaining intracellular levels of NAD is crucial for the management of stress response of cells. Here we show that agonist-induced cardiac hypertrophy is associated with loss of intracellular levels of NAD, bu...

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Detalhes bibliográficos
Main Authors: Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Kim, Gene, Gupta, Madhu, Rajamohan, Senthilkumar B., Pillai, Jyothish B., Samant, Sadhana, Ravindra, P. V., Isbatan, Ayman, Gupta, Mahesh P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823454/
https://ncbi.nlm.nih.gov/pubmed/19940131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077271
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