SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

Poly(ADP-ribose) polymerase 1 (PARP1) and SIRT1 deacetylase are two NAD-dependent enzymes which play major roles in the decision of a cell to live or to die in a stress situation. Because of the dependence of both enzymes on NAD, cross talk between them has been suggested. Here, we show that PARP1 i...

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Main Authors: Rajamohan, Senthilkumar B., Pillai, Vinodkumar B., Gupta, Madhu, Sundaresan, Nagalingam R., Birukov, Konstantin G., Samant, Sadhana, Hottiger, Michael O., Gupta, Mahesh P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715814/
https://ncbi.nlm.nih.gov/pubmed/19470756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00121-09
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