Electrophilic nitro-fatty acids prevent astrocyte-mediated toxicity to motor neurons in a cell model of familial amyotrophic lateral sclerosis via nuclear factor erythroid 2-related factor activation

Nitro-fatty acids (NO(2)-FA) are electrophilic signaling mediators formed in tissues during inflammation, which are able to induce pleiotropic cytoprotective and antioxidant pathways including up regulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) responsive genes. Amyotrophic Lateral S...

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Udgivet i:Free Radic Biol Med
Main Authors: Diaz-Amarilla, Pablo, Miquel, Ernesto, Trostchansky, Andrés, Trias, Emiliano, Ferreira, Ana M., Freeman, Bruce A., Cassina, Patricia, Barbeito, Luis, Vargas, Marcelo R., Rubbo, Homero
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867302/
https://ncbi.nlm.nih.gov/pubmed/27012417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.03.013
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