Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity

We investigated the mechanism of selective ascorbate-induced cytotoxicity in tumor cells, including Hep G2 cells, compared to primary hepatocytes. H(2)O(2) formation was required for ascorbate cytotoxicity, as extracellular catalase treatment protected tumor cells. H(2)O(2) generated by glucose oxid...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Free Radic Biol Med
Prif Awduron: Rouleau, Lauren, Antony, Anil Noronha, Bisetto, Sara, Newberg, Andrew, Doria, Cataldo, Levine, Mark, Monti, Daniel A., Hoek, Jan B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867251/
https://ncbi.nlm.nih.gov/pubmed/27036367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.03.031
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