Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity

We investigated the mechanism of selective ascorbate-induced cytotoxicity in tumor cells, including Hep G2 cells, compared to primary hepatocytes. H(2)O(2) formation was required for ascorbate cytotoxicity, as extracellular catalase treatment protected tumor cells. H(2)O(2) generated by glucose oxid...

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Pubblicato in:Free Radic Biol Med
Autori principali: Rouleau, Lauren, Antony, Anil Noronha, Bisetto, Sara, Newberg, Andrew, Doria, Cataldo, Levine, Mark, Monti, Daniel A., Hoek, Jan B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867251/
https://ncbi.nlm.nih.gov/pubmed/27036367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.03.031
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