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Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity
We investigated the mechanism of selective ascorbate-induced cytotoxicity in tumor cells, including Hep G2 cells, compared to primary hepatocytes. H(2)O(2) formation was required for ascorbate cytotoxicity, as extracellular catalase treatment protected tumor cells. H(2)O(2) generated by glucose oxid...
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| Publicado no: | Free Radic Biol Med |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4867251/ https://ncbi.nlm.nih.gov/pubmed/27036367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.03.031 |
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