Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity

We investigated the mechanism of selective ascorbate-induced cytotoxicity in tumor cells, including Hep G2 cells, compared to primary hepatocytes. H(2)O(2) formation was required for ascorbate cytotoxicity, as extracellular catalase treatment protected tumor cells. H(2)O(2) generated by glucose oxid...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Rouleau, Lauren, Antony, Anil Noronha, Bisetto, Sara, Newberg, Andrew, Doria, Cataldo, Levine, Mark, Monti, Daniel A., Hoek, Jan B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867251/
https://ncbi.nlm.nih.gov/pubmed/27036367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.03.031
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