Simultaneous quantitative determination of 5-aza-2′-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors

The epigenetic and anti-cancer activities of the nucleoside analog DNA methyltransferase (DNMT) inhibitors decitabine (5-aza-2′-deoxycytidine, DAC), azacitidine, and guadecitabine are thought to require cellular uptake, metabolism to 5-aza-2′-deoxycytidine triphosphate, and incorporation into DNA. T...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Anders, Nicole M., Liu, Jianyong, Wanjiku, Teresia, Giovinazzo, Hugh, Zhou, Jianya, Vaghasia, Ajay, Nelson, William G., Yegnasubramanian, Srinivasan, Rudek, Michelle A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866886/
https://ncbi.nlm.nih.gov/pubmed/27082761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.03.029
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados