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Broad Spectrum Enolate Equivalent for Catalytic Chemo-, Diastereo-, and Enantioselective Addition to N-Boc Imines

Alkynyl ketones are attractive but challenging nucleophiles in enolate chemistry. Their susceptibility to other reactions such as Michael additions and the difficulty of controlling the enolate geometry make them difficult substrates. Mannich-type reactions, which previously have not been reported u...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Trost, Barry M., Hung, Chao-I (Joey)
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866649/
https://ncbi.nlm.nih.gov/pubmed/26630114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11248
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