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Structural basis for the blockade of MATE multidrug efflux pumps

Multidrug and toxic compound extrusion (MATE) transporters underpin multidrug resistance by using the H(+) or Na(+) electrochemical gradient to extrude different drugs across cell membranes. MATE transporters can be further parsed into the DinF, NorM and eukaryotic subfamilies based on their amino-a...

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Publicado en:Nat Commun
Main Authors: Radchenko, Martha, Symersky, Jindrich, Nie, Rongxin, Lu, Min
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866600/
https://ncbi.nlm.nih.gov/pubmed/26246409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8995
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