Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells

mTOR is aberrantly activated in hepatocellular carcinoma (HCC) and plays pivotal roles in tumorigenesis and chemoresistance. Rapamycin has been reported to exert antitumor activity in HCC and sensitizes HCC cells to cytotoxic agents. However, due to feedback activation of AKT after mTOR complex 1 (m...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Ther
Huvudupphovsmän: Chen, Bryan Wei, Chen, Wei, Liang, Hui, Liu, Hao, Liang, Chao, Zhi, Xiao, Hu, Li-qiang, Yu, Xia-Zhen, Wei, Tao, Ma, Tao, Xue, Fei, Zheng, Lei, Zhao, Bin, Feng, Xin-Hua, Bai, Xue-li, Liang, Ting-bo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866512/
https://ncbi.nlm.nih.gov/pubmed/26026051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0029
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