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Universal allosteric mechanism for Gα activation by GPCRs
G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and trigger GDP release. Given that there are ~800 human GPCRs and 16 different Gα proteins, does a universal allosteric mechanism govern Gα activation? Here we show that different GPCRs interact and activate Gα pr...
Tallennettuna:
| Julkaisussa: | Nature |
|---|---|
| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4866443/ https://ncbi.nlm.nih.gov/pubmed/26147082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14663 |
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