Universal allosteric mechanism for Gα activation by GPCRs

G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and trigger GDP release. Given that there are ~800 human GPCRs and 16 different Gα proteins, does a universal allosteric mechanism govern Gα activation? Here we show that different GPCRs interact and activate Gα pr...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Nature
Hoofdauteurs: Flock, Tilman, Ravarani, Charles N. J., Sun, Dawei, Venkatakrishnan, A. J., Kayikci, Melis, Tate, Christopher G., Veprintsev, Dmitry B., Babu, M. Madan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866443/
https://ncbi.nlm.nih.gov/pubmed/26147082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14663
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items