The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling

FGF21 is an atypical member of the FGF family that functions as a hormone to regulate carbohydrate and lipid metabolism. Here we demonstrate that the actions of FGF21 in mouse adipose tissue, but not in liver, are modulated by the nuclear receptor Rev-erbα, a potent transcriptional repressor. Interr...

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Vydáno v:J Biol Chem
Hlavní autoři: Jager, Jennifer, Wang, Fenfen, Fang, Bin, Lim, Hee-Woong, Peed, Lindsey C., Steger, David J., Won, Kyoung-Jae, Kharitonenkov, Alexei, Adams, Andrew C., Lazar, Mitchell A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865931/
https://ncbi.nlm.nih.gov/pubmed/27002153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.719120
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