The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator

Methionine is an essential sulfur amino acid that is engaged in key cellular functions such as protein synthesis and is a precursor for critical metabolites involved in maintaining cellular homeostasis. In mammals, in response to nutrient conditions, the liver plays a significant role in regulating...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Tavares, Clint D. J., Sharabi, Kfir, Dominy, John E., Lee, Yoonjin, Isasa, Marta, Orozco, Jose M., Jedrychowski, Mark P., Kamenecka, Theodore M., Griffin, Patrick R., Gygi, Steven P., Puigserver, Pere
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865912/
https://ncbi.nlm.nih.gov/pubmed/27022023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.706200
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