Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR

The carbohydrate-response element-binding protein (ChREBP) is a glucose-responsive transcription factor that plays an essential role in converting excess carbohydrate to fat storage in the liver. In response to glucose levels, ChREBP is regulated by nuclear/cytosol trafficking via interaction with 1...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Sato, Shogo, Jung, Hunmin, Nakagawa, Tsutomu, Pawlosky, Robert, Takeshima, Tomomi, Lee, Wan-Ru, Sakiyama, Haruhiko, Laxman, Sunil, Wynn, R. Max, Tu, Benjamin P., MacMillan, John B., De Brabander, Jef K., Veech, Richard L., Uyeda, Kosaku
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865902/
https://ncbi.nlm.nih.gov/pubmed/26984404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708982
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