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Neighbor-directed Histidine N(τ)–Alkylation: A Route to Imidazolium-containing Phosphopeptide Macrocycles

Our recently discovered, selective, on-resin route to N(τ)-alkylated imidazolium-containing histidine residues affords new strategies for peptide mimetic design. In our current work, we demonstrate the use of this chemistry to prepare a series of macrocyclic phosphopeptides, in which imidazolium gro...

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Vydáno v:Biopolymers
Hlavní autoři: Qian, Wen-Jian, Park, Jung-Eun, Grant, Robert, Lai, Christopher C., Kelley, James A., Yaffe, Michael B., Lee, Kyung S., Burke, Terrence R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865893/
https://ncbi.nlm.nih.gov/pubmed/26152807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22698
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