Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke

We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO(2) extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We showed that one component of this neuroprotective activity is mediated through its princip...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Van Kanegan, Michael J., Dunn, Denise E., Kaltenbach, Linda S., Shah, Bijal, He, Dong Ning, McCoy, Daniel D., Yang, Peiying, Peng, Jiangnan, Shen, Li, Du, Lin, Cichewicz, Robert H., Newman, Robert A., Lo, Donald C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865873/
https://ncbi.nlm.nih.gov/pubmed/27172999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25626
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