Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke

We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO(2) extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We showed that one component of this neuroprotective activity is mediated through its princip...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Van Kanegan, Michael J., Dunn, Denise E., Kaltenbach, Linda S., Shah, Bijal, He, Dong Ning, McCoy, Daniel D., Yang, Peiying, Peng, Jiangnan, Shen, Li, Du, Lin, Cichewicz, Robert H., Newman, Robert A., Lo, Donald C.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865873/
https://ncbi.nlm.nih.gov/pubmed/27172999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25626
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