The Botanical Drug PBI-05204, a Supercritical CO(2) Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties

Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-suppor...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Colapietro, Alessandro, Yang, Peiying, Rossetti, Alessandra, Mancini, Andrea, Vitale, Flora, Martellucci, Stefano, Conway, Tara L., Chakraborty, Sharmistha, Marampon, Francesco, Mattei, Vincenzo, Gravina, Giovanni Luca, Biordi, Assunta Leda, Wei, Daoyan, Newman, Robert A., Festuccia, Claudio
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516200/
https://ncbi.nlm.nih.gov/pubmed/33013390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.552428
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