PBI-05204, a supercritical CO(2) extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway

Introduction Oleandrin, a cardiac glycoside, exerts strong anti-proliferative activity against various human malignancies in in vitro cells. Here, we report the antitumor efficacy of PBI-05204, a supercritical C0(2) extract of Nerium oleander containing oleandrin, in a human pancreatic cancer Panc-1...

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Bibliografiske detaljer
Udgivet i:Invest New Drugs
Main Authors: Pan, Yong, Rhea, Patrea, Tan, Lin, Cartwright, Carrie, Lee, Ho-Jeong, Ravoori, Murali K., Addington, Crandell, Gagea, Mihai, Kundra, Vikas, Kim, Sun-Jin, Newman, Robert A., Yang, Peiying
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2014
Fag:
Preclinical Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387257/
https://ncbi.nlm.nih.gov/pubmed/25476893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0190-6
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