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Regulation of neuronal chloride homeostasis by neuromodulators

KCC2 is the central regulator of neuronal Cl(−) homeostasis, and is critical for enabling strong hyperpolarizing synaptic inhibition in the mature brain. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous disease states including epileps...

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Bibliografske podrobnosti
izdano v:J Physiol
Main Authors: Mahadevan, Vivek, Woodin, Melanie A.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865579/
https://ncbi.nlm.nih.gov/pubmed/26876607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271593
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