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Regulation of neuronal chloride homeostasis by neuromodulators
KCC2 is the central regulator of neuronal Cl(−) homeostasis, and is critical for enabling strong hyperpolarizing synaptic inhibition in the mature brain. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous disease states including epileps...
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| Pubblicato in: | J Physiol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4865579/ https://ncbi.nlm.nih.gov/pubmed/26876607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271593 |
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