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Acid‐sensing ion channels are tuned to follow high‐frequency stimuli

KEY POINTS: Acid‐sensing ion channels (ASICs) act as neurotransmitter receptors by responding to synaptic cleft acidification. We investigated how ASIC1a homomers and ASIC1a/2a heteromers respond to brief stimuli, jumping from pH 8.0 to 5.0, approximating the time course of neurotransmitter in the c...

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Pubblicato in:J Physiol
Autori principali: MacLean, David M., Jayaraman, Vasanthi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865573/
https://ncbi.nlm.nih.gov/pubmed/26931316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271915
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