Intracellular soluble α‐synuclein oligomers reduce pyramidal cell excitability

KEY POINTS: The presynaptic protein α‐synuclein forms aggregates during Parkinson's disease. Accumulating evidence suggests that the small soluble oligomers of α‐synuclein are more toxic than the larger aggregates appearing later in the disease. The link between oligomer toxicity and structure...

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Udgivet i:J Physiol
Main Authors: Kaufmann, Timothy J., Harrison, Paul M., Richardson, Magnus J. E., Pinheiro, Teresa J. T., Wall, Mark J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Neuroscience ‐ Neurobiology of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865569/
https://ncbi.nlm.nih.gov/pubmed/26915902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271968
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