Intracellular soluble α‐synuclein oligomers reduce pyramidal cell excitability

KEY POINTS: The presynaptic protein α‐synuclein forms aggregates during Parkinson's disease. Accumulating evidence suggests that the small soluble oligomers of α‐synuclein are more toxic than the larger aggregates appearing later in the disease. The link between oligomer toxicity and structure...

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Bibliografske podrobnosti
izdano v:J Physiol
Main Authors: Kaufmann, Timothy J., Harrison, Paul M., Richardson, Magnus J. E., Pinheiro, Teresa J. T., Wall, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Neuroscience ‐ Neurobiology of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865569/
https://ncbi.nlm.nih.gov/pubmed/26915902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271968
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