Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2

In response to diverse stimuli, two-pore-domain potassium channel TREK-2 regulates cellular excitability, and hence plays a key role in mediating neuropathic pain, mood disorders and ischemia through. Although more and more input modalities are found to achieve their modulations via acting on the ch...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Zhuo, Ren-Gong, Peng, Peng, Liu, Xiao-Yan, Yan, Hai-Tao, Xu, Jiang-Ping, Zheng, Jian-Quan, Wei, Xiao-Li, Ma, Xiao-Yun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865513/
https://ncbi.nlm.nih.gov/pubmed/27242438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00127
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