External Ba(2+) Block of the Two-pore Domain Potassium Channel TREK-1 Defines Conformational Transition in Its Selectivity Filter

TREK-1 is a member of the two-pore domain potassium channel family that is known as a leak channel and plays a key role in many physiological and pathological processes. The conformational transition of the selectivity filter is considered as an effective strategy for potassium channels to control t...

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Bibliographic Details
Main Authors: Ma, Xiao-Yun, Yu, Jin-Mei, Zhang, Shu-Zhuo, Liu, Xiao-Yan, Wu, Bao-Hong, Wei, Xiao-Li, Yan, Jia-Qing, Sun, Hong-Liang, Yan, Hai-Tao, Zheng, Jian-Quan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220548/
https://ncbi.nlm.nih.gov/pubmed/21965685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264788
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