The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction

Cardiac two-pore domain potassium channels (K2P) exist in organisms from Drosophila to humans; however, their role in cardiac function is not known. We identified a K2P gene, CG8713 (sandman), in a Drosophila genetic screen and show that sandman is critical to cardiac function. Mice lacking an ortho...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Abraham, Dennis M., Lee, Teresa E., Watson, Lewis J., Mao, Lan, Chandok, Gurangad, Wang, Hong-Gang, Frangakis, Stephan, Pitt, Geoffrey S., Shah, Svati H., Wolf, Matthew J., Rockman, Howard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205385/
https://ncbi.nlm.nih.gov/pubmed/30153110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95945
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