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Molecular Mechanisms of Suberoylanilide Hydroxamic Acid (SAHA) in the Inhibition of TGF-β1 Mediated Canine Corneal Fibrosis

OBJECTIVE: To investigate molecular mechanisms mediating anti-fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad-dependent and, to a lesser extent, Smad-independent signaling pathways activated by TGF-β1, as...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Vet Ophthalmol
Egile Nagusiak: Gronkiewicz, Kristina M., Giuliano, Elizabeth A., Sharma, Ajay, Mohan, Rajiv R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865451/
https://ncbi.nlm.nih.gov/pubmed/26559782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/vop.12331
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