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Real-time HD Exchange Kinetics of Proteins from Buffered Aqueous Solution with Electrothermal Supercharging and Top-Down Tandem Mass Spectrometry

Electrothermal supercharging (ETS) with electrospray ionization produces highly charged protein ions from buffered aqueous solutions in which proteins have native folded structures. ETS increases the charge of ribonuclease A by 34% whereas only a 6% increase in charge occurs for a reduced alkylated...

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Foilsithe in:J Am Soc Mass Spectrom
Main Authors: Going, Catherine C., Xia, Zijie, Williams, Evan R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865425/
https://ncbi.nlm.nih.gov/pubmed/26919868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-016-1350-z
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