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Engineering therapeutic protein disaggregases

Therapeutic agents are urgently required to cure several common and fatal neurodegenerative disorders caused by protein misfolding and aggregation, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD). Protein disaggregases that reverse protein misfol...

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Publicado en:Mol Biol Cell
Autor principal: Shorter, James
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2016
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865313/
https://ncbi.nlm.nih.gov/pubmed/27255695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-10-0693
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