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Reversing deleterious protein aggregation with re-engineered protein disaggregases

Aberrant protein folding is severely problematic and manifests in numerous disorders, including amyotrophic lateral sclerosis (ALS), Parkinson disease (PD), Huntington disease (HD), and Alzheimer disease (AD). Patients with each of these disorders are characterized by the accumulation of mislocalize...

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Detalhes bibliográficos
Main Authors: Jackrel, Meredith E, Shorter, James
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050135/
https://ncbi.nlm.nih.gov/pubmed/24694655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28709
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