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Reversing deleterious protein aggregation with re-engineered protein disaggregases

Aberrant protein folding is severely problematic and manifests in numerous disorders, including amyotrophic lateral sclerosis (ALS), Parkinson disease (PD), Huntington disease (HD), and Alzheimer disease (AD). Patients with each of these disorders are characterized by the accumulation of mislocalize...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jackrel, Meredith E, Shorter, James
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050135/
https://ncbi.nlm.nih.gov/pubmed/24694655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28709
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