CD90(+) stromal cells are the major source of IL-6 which supports cancer stem-like cells and inflammation in colorectal cancer

IL-6 is a pleiotropic cytokine increased in CRC and known to directly promote tumor growth. Colonic myofibroblasts/fibroblasts (CMFs or stromal cells) are CD90(+) innate immune cells representing up to 30% of normal colonic mucosal lamina propria cells. They are expanded in CRC tumor stroma, where t...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Huynh, Phuong T., Beswick, Ellen J., Coronado, Yun A., Johnson, Paul, O'Connell, Malaney R., Watts, Tammara, Singh, Pomila, Qiu, Suimin, Morris, Katherine, Powell, Don W., Pinchuk, Irina V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865268/
https://ncbi.nlm.nih.gov/pubmed/26595254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29939
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