CD90(+) stromal cells are the major source of IL-6 which supports cancer stem-like cells and inflammation in colorectal cancer

IL-6 is a pleiotropic cytokine increased in CRC and known to directly promote tumor growth. Colonic myofibroblasts/fibroblasts (CMFs or stromal cells) are CD90(+) innate immune cells representing up to 30% of normal colonic mucosal lamina propria cells. They are expanded in CRC tumor stroma, where t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Cancer
Prif Awduron: Huynh, Phuong T., Beswick, Ellen J., Coronado, Yun A., Johnson, Paul, O'Connell, Malaney R., Watts, Tammara, Singh, Pomila, Qiu, Suimin, Morris, Katherine, Powell, Don W., Pinchuk, Irina V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865268/
https://ncbi.nlm.nih.gov/pubmed/26595254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29939
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