Effect of the specific proteasome inhibitor bortezomib on cancer‐related muscle wasting

BACKGROUND: Muscle wasting, a prominent feature of cancer cachexia, is mainly caused by sustained protein hypercatabolism. The enhanced muscle protein degradation rates rely on the activity of different proteolytic systems, although the Adenosine triphosphate (ATP)‐ubiquitin‐proteasome‐dependent pat...

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Veröffentlicht in:J Cachexia Sarcopenia Muscle
Hauptverfasser: Penna, Fabio, Bonetto, Andrea, Aversa, Zaira, Minero, Valerio Giacomo, Rossi Fanelli, Filippo, Costelli, Paola, Muscaritoli, Maurizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864285/
https://ncbi.nlm.nih.gov/pubmed/27239411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12050
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