Human Cytochrome P450 27C1 Catalyzes 3,4-Desaturation of Retinoids

In humans, a considerable fraction of the retinoid pool in skin is derived from vitamin A(2) (all-trans 3,4-dehydroretinal). Vitamin A(2) may be locally generated by keratinocytes, which can convert vitamin A(1) (all-trans retinol) into vitamin A(2) in cell culture. We report that human cytochrome P...

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Publicado en:FEBS Lett
Autores principales: Kramlinger, Valerie M., Nagy, Leslie D., Fujiwara, Rina, Johnson, Kevin M., Phan, Thanh T. N., Xiao, Yi, Enright, Jennifer M., Toomey, Matthew B., Corbo, Joseph C., Guengerich, F. Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864060/
https://ncbi.nlm.nih.gov/pubmed/27059013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12167
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