Neutrophil Interaction with the Hemostatic System Contributes to Liver Injury in Rats Cotreated with Lipopolysaccharide and Ranitidine

Cotreatment of rats with nontoxic doses of ranitidine (RAN) and lipopolysaccharide (LPS) causes liver injury, and this drug-inflammation interaction might be a model for idiosyncratic adverse drug responses in humans. Both polymorphonuclear neutrophils (PMNs) and the hemostatic system have been show...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Deng, Xiaomin, Luyendyk, James P., Zou, Wei, Lu, Jingtao, Malle, Ernst, Ganey, Patricia E., Roth, Robert A.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863953/
https://ncbi.nlm.nih.gov/pubmed/17505017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.122069
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