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Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment
Among all the nonsteroidal anti-inflammatory drugs, sulindac (SLD) is associated with the greatest incidence of idiosyncratic hepatotoxicity in humans. Previously, an animal model of SLD-induced idiosyncratic hepatotoxicity was developed by cotreating rats with a nonhepatotoxic dose of LPS. Tumor ne...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898510/ https://ncbi.nlm.nih.gov/pubmed/20371263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2010.03.015 |
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