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A scalable method for the production of high-titer and high-quality adeno-associated type 9 vectors using the HSV platform

Recombinant adeno-associated vectors based on serotype 9 (rAAV9) have demonstrated highly effective gene transfer in multiple animal models of muscular dystrophies and other neurological indications. Current limitations in vector production and purification have hampered widespread implementation of...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Adamson-Small, Laura, Potter, Mark, Falk, Darin J, Cleaver, Brian, Byrne, Barry J, Clément, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863725/
https://ncbi.nlm.nih.gov/pubmed/27222839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.31
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