STAT3 Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

BACKGROUND & AIMS: A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the presence of a dense desmoplastic reaction (stroma) that impedes drug delivery to the tumor. Attempts to deplete the tumor stroma have resulted in formation of more aggressive tumors. We have identified STAT3 as a bio...

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Veröffentlicht in:Gastroenterology
Hauptverfasser: Nagathihalli, Nagaraj S., Castellanos, Jason A., Shi, Chanjuan, Beesetty, Yugandhar, Reyzer, Michelle L., Caprioli, Richard, Chen, Xi, Walsh, Alex J., Skala, Melissa C., Moses, Harold L., Merchant, Nipun B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863449/
https://ncbi.nlm.nih.gov/pubmed/26255562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.07.058
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