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Opposite transcriptional regulation of integrated vs unintegrated HIV genomes by the NF-κB pathway
Integration of HIV-1 linear DNA into host chromatin is required for high levels of viral expression, and constitutes a key therapeutic target. Unintegrated viral DNA (uDNA) can support only limited transcription but may contribute to viral propagation, persistence and/or treatment escape under speci...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4863372/ https://ncbi.nlm.nih.gov/pubmed/27167871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25678 |
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