Opposite transcriptional regulation of integrated vs unintegrated HIV genomes by the NF-κB pathway

Integration of HIV-1 linear DNA into host chromatin is required for high levels of viral expression, and constitutes a key therapeutic target. Unintegrated viral DNA (uDNA) can support only limited transcription but may contribute to viral propagation, persistence and/or treatment escape under speci...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Thierry, Sylvain, Thierry, Eloïse, Subra, Frédéric, Deprez, Eric, Leh, Hervé, Bury-Moné, Stéphanie, Delelis, Olivier
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863372/
https://ncbi.nlm.nih.gov/pubmed/27167871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25678
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