Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes

BACKGROUND: Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma membrane potassium channel. Blocking KCa1.1 reduces the invasive phenotype...

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Dettagli Bibliografici
Pubblicato in:Arthritis Res Ther
Autori principali: Pethő, Zoltán, Tanner, Mark R., Tajhya, Rajeev B., Huq, Redwan, Laragione, Teresina, Panyi, Gyorgy, Gulko, Pércio S., Beeton, Christine
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863321/
https://ncbi.nlm.nih.gov/pubmed/27165430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1003-4
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