KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

Abstract Background Fibroblast-like synoviocytes (FLS) and CCR7− effector memory T (TEM) cells are two of the major cell types implicated in the progression of rheumatoid arthritis (RA). In particular, FLS become highly invasive, whereas TEM cells proliferate and secrete proinflammatory cytokines, d...

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Detalhes bibliográficos
Main Authors: Mark R. Tanner, Michael W. Pennington, Satendra S. Chauhan, Teresina Laragione, Pércio S. Gulko, Christine Beeton
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-01-01
Colecção:Arthritis Research & Therapy
Assuntos:
Synovial fibroblast
Immunomodulation
Cell interactions
Dual therapy
Autoimmunity
Acesso em linha:http://link.springer.com/article/10.1186/s13075-018-1783-9
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