KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates rat models of rheumatoid arthritis

OBJECTIVE: Fibroblast-like synoviocytes (FLS) participate in joint inflammation and damage during rheumatoid arthritis (RA) and its animal models. The purpose of this study was to define the importance of KCa1.1 (BK, Maxi-K, Slo1, KCNMA1) channel expression and function in FLS and to establish these...

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Publicado no:Arthritis Rheumatol
Main Authors: Tanner, Mark R., Hu, Xueyou, Huq, Redwan, Tajhya, Rajeev B., Sun, Liang, Khan, Fatima S., Laragione, Teresina, Horrigan, Frank T., Gulko, Pércio S., Beeton, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280298/
https://ncbi.nlm.nih.gov/pubmed/25252152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38883
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